Katherine A. Hoadley1<\/sup>, <\/sup>20<\/sup>,\u00a0Christina Yau2<\/sup>, <\/sup>20<\/sup>,\u00a0Denise M. Wolf3<\/sup>, <\/sup>20<\/sup>,\u00a0Andrew D. Cherniack4<\/sup>, <\/sup>20<\/sup>,\u00a0David Tamborero5<\/sup>,\u00a0Sam Ng6<\/sup>,\u00a0Max D.M. Leiserson7<\/sup>,\u00a0Beifang Niu8<\/sup>,\u00a0Michael D. McLellan8<\/sup>,\u00a0Vladislav Uzunangelov6<\/sup>,\u00a0Jiashan Zhang9<\/sup>,\u00a0Cyriac Kandoth8<\/sup>,\u00a0Rehan Akbani10<\/sup>,\u00a0Hui Shen11<\/sup>, <\/sup>22<\/sup>,\u00a0Larsson Omberg12<\/sup>,\u00a0Andy Chu13<\/sup>,\u00a0Adam A. Margolin12<\/sup>, <\/sup>21<\/sup>,\u00a0Laura J. van\u2019t Veer3<\/sup>,\u00a0Nuria Lopez-Bigas5<\/sup>, <\/sup>14<\/sup>,\u00a0Peter W. Laird11<\/sup>, <\/sup>22<\/sup>,\u00a0Benjamin J. Raphael7<\/sup>,\u00a0Li Ding8<\/sup>,\u00a0A. Gordon Robertson13<\/sup>,\u00a0Lauren A. Byers10<\/sup>,\u00a0Gordon B. Mills10<\/sup>,\u00a0John N. Weinstein10<\/sup>,\u00a0Carter Van Waes18<\/sup>,\u00a0Zhong Chen19<\/sup>,\u00a0Eric A. Collisson15<\/sup>,The Cancer Genome Atlas Research Network,\u00a0Christopher C. Benz2<\/sup>, <\/sup>, <\/sup>, Charles M. Perou1<\/sup>, <\/sup>16<\/sup>, <\/sup>17<\/sup>, <\/sup>, <\/sup>, Joshua M. Stuart6<\/sup>, <\/sup>,<\/sup><\/p>\n 1<\/sup> Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA<\/span> Recent genomic analyses of pathologically defined tumor types identify \u201cwithin-a-tissue\u201d disease subtypes. However, the extent to which genomic signatures are shared across tissues is still unclear. We\u00a0performed an integrative analysis using five genome-wide platforms and one proteomic platform on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes. Five subtypes were nearly identical to their tissue-of-origin counterparts, but several distinct cancer types were found to converge into common subtypes. Lung\u00a0squamous, head and neck, and a subset of bladder cancers coalesced into one subtype typified by TP53 alterations, TP63 amplifications, and high expression of immune and proliferation pathway genes. Of note, bladder cancers split into three pan-cancer subtypes. The multiplatform classification, while correlated with tissue-of-origin, provides independent information for predicting clinical outcomes. All data sets are available for data-mining from a unified resource to support further biological discoveries and insights into novel therapeutic strategies.<\/p>\n<\/div>\n Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin Katherine A. Hoadley1, 20,\u00a0Christina Yau2, 20,\u00a0Denise M. Wolf3, 20,\u00a0Andrew D. Cherniack4, 20,\u00a0David Tamborero5,\u00a0Sam Ng6,\u00a0Max D.M. Leiserson7,\u00a0Beifang Niu8,\u00a0Michael D. McLellan8,\u00a0Vladislav Uzunangelov6,\u00a0Jiashan Zhang9,\u00a0Cyriac Kandoth8,\u00a0Rehan Akbani10,\u00a0Hui Shen11, 22,\u00a0Larsson Omberg12,\u00a0Andy Chu13,\u00a0Adam A. Margolin12, 21,\u00a0Laura J. van\u2019t Veer3,\u00a0Nuria Lopez-Bigas5, 14,\u00a0Peter W. Laird11, 22,\u00a0Benjamin J. Raphael7,\u00a0Li […]<\/p>\n","protected":false},"author":88,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[4,49,50,51],"_links":{"self":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/152"}],"collection":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/users\/88"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/comments?post=152"}],"version-history":[{"count":1,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/152\/revisions"}],"predecessor-version":[{"id":153,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/152\/revisions\/153"}],"wp:attachment":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/media?parent=152"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/categories?post=152"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/tags?post=152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n2<\/sup> Buck Institute for Research on Aging, Novato, CA 94945, USA<\/span>
\n3<\/sup> Department of Laboratory Medicine, University of California San Francisco, 2340 Sutter St, San Francisco, CA, 94115, USA<\/span>
\n4<\/sup> The Eli and Edythe Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA<\/span>
\n5<\/sup> Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona 08003, Spain<\/span>
\n6<\/sup> Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA<\/span>
\n7<\/sup> Department of Computer Science and Center for Computational Molecular Biology, Brown University, 115 Waterman St, Providence RI 02912, USA<\/span>
\n8<\/sup> The Genome Institute, Washington University, St Louis, MO 63108, USA<\/span>
\n9<\/sup> National Cancer Institute, NIH, Bethesda, MD 20892, USA<\/span>
\n10<\/sup> UT MD Anderson Cancer Center, Bioinformatics and Computational Biology, 1400 Pressler Street, Unit 1410, Houston, TX 77030, USA<\/span>
\n11<\/sup> USC Epigenome Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA<\/span>
\n12<\/sup> Sage Bionetworks 1100 Fairview Avenue North, M1-C108, Seattle, WA 98109-1024, USA<\/span>
\n13<\/sup> Canada\u2019s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada<\/span>
\n14<\/sup> Catalan Institution for Research and Advanced Studies (ICREA), Passeig Llu\u00eds Companys, 23, Barcelona 08010, Spain<\/span>
\n15<\/sup> Department of Medicine, University of California San Francisco, 450 35d St, San Francisco, CA, 94148, USA<\/span>
\n16<\/sup> Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA<\/span>
\n17<\/sup> Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA<\/span>
\n18<\/sup> Building 10, Room 4-2732, NIDCD\/NIH, 10 Center Drive, Bethesda, MD 20892<\/span>
\n19<\/sup> Head and Neck Surgery Branch, NIDCD\/NIH, 10 Center Drive, Room 5D55, Bethesda, MD 20892<\/span><\/p>\n\n
Summary<\/h2>\n
\n<\/div>\n<\/dd>\n<\/dl>\n","protected":false},"excerpt":{"rendered":"