{"id":411,"date":"2016-07-13T12:41:38","date_gmt":"2016-07-13T17:41:38","guid":{"rendered":"http:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/?p=411"},"modified":"2016-07-13T13:08:29","modified_gmt":"2016-07-13T18:08:29","slug":"epigenomic-co-localization-and-co-evolution-reveal-a-key-role-for-5hmc-as-a-communication-hub-in-the-chromatin-network-of-escs","status":"publish","type":"post","link":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/2016\/07\/13\/epigenomic-co-localization-and-co-evolution-reveal-a-key-role-for-5hmc-as-a-communication-hub-in-the-chromatin-network-of-escs\/","title":{"rendered":"Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs"},"content":{"rendered":"<p>Our selected paper for this week is titled <a href=\"http:\/\/www.cell.com\/cell-reports\/pdf\/S2211-1247(16)00028-0.pdf\">Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs<\/a>, from Cell.The abstract is as follows:<\/p>\n<blockquote><p>Epigenetic communication through histone and cytosine modifications is essential for gene regula- tion and cell identity. Here, we propose a framework that is based on a chromatin communication model to get insight on the function of epigenetic modifica- tions in ESCs. The epigenetic communication network was inferred from genome-wide location data plus extensive manual annotation. Notably, we found that 5-hydroxymethylcytosine (5hmC) is the most-influential hub of this network, connecting DNA demethylation to nucleosome remodeling complexes and to key transcription factors of plurip- otency. Moreover, an evolutionary analysis revealed a central role of 5hmC in the co-evolution of chro- matin-related proteins. Further analysis of regions where 5hmC co-localizes with specific interactors shows that each interaction points to chromatin remodeling, stemness, differentiation, or meta- bolism. Our results highlight the importance of cyto- sine modifications in the epigenetic communication of ESCs.<\/p><\/blockquote>\n<p>Feel free to begin our discussion in the comments section below. Our meeting will be at 12:30 PM in room 3160 of the Discovery building on July 18th. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our selected paper for this week is titled Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs, from Cell.The abstract is as follows: Epigenetic communication through histone and cytosine modifications is essential for gene regula- tion and cell identity. Here, we propose a framework [&hellip;]<\/p>\n","protected":false},"author":124,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[103,108],"tags":[109,38,90],"_links":{"self":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/411"}],"collection":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/users\/124"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/comments?post=411"}],"version-history":[{"count":1,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/411\/revisions"}],"predecessor-version":[{"id":412,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/411\/revisions\/412"}],"wp:attachment":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/media?parent=411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/categories?post=411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/tags?post=411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}