{"id":554,"date":"2017-08-28T13:23:32","date_gmt":"2017-08-28T18:23:32","guid":{"rendered":"http:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/?p=554"},"modified":"2017-08-28T13:23:32","modified_gmt":"2017-08-28T18:23:32","slug":"an-expanded-view-of-complex-traits-from-polygenic-to-omnigenic","status":"publish","type":"post","link":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/2017\/08\/28\/an-expanded-view-of-complex-traits-from-polygenic-to-omnigenic\/","title":{"rendered":"An Expanded View of Complex Traits: From Polygenic to Omnigenic"},"content":{"rendered":"<p>Our next meeting will be at 2:30 on September 1st, in room 4160 of the Discovery building. Our Selected paper is <a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867417306293#sec1\">An Expanded View of Complex Traits: From Polygenic to Omnigenic<\/a>.<br \/>\nThe abstract is as follows.<\/p>\n<blockquote><p>A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect disease-causing variants to cluster into key pathways that drive disease etiology. But for complex traits, association signals tend to be spread across most of the genome\u2014including near many genes without an obvious connection to disease. We propose that gene regulatory networks are sufficiently interconnected such that all genes expressed in disease-relevant cells are liable to affect the functions of core disease-related genes and that most heritability can be explained by effects on genes outside core pathways. We refer to this hypothesis as an \u201comnigenic\u201d model.<\/p><\/blockquote>\n<p>We welcome all who can join us for this discussion. Feel free to begin that discussion in the comments section below.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our next meeting will be at 2:30 on September 1st, in room 4160 of the Discovery building. Our Selected paper is An Expanded View of Complex Traits: From Polygenic to Omnigenic. The abstract is as follows. A central goal of genetics is to understand the links between genetic variation and disease. Intuitively, one might expect [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[113,124],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/554"}],"collection":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/comments?post=554"}],"version-history":[{"count":1,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/554\/revisions"}],"predecessor-version":[{"id":555,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/554\/revisions\/555"}],"wp:attachment":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/media?parent=554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/categories?post=554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/tags?post=554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}