{"id":566,"date":"2017-09-22T12:13:03","date_gmt":"2017-09-22T17:13:03","guid":{"rendered":"http:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/?p=566"},"modified":"2017-09-22T12:14:45","modified_gmt":"2017-09-22T17:14:45","slug":"reversed-graph-embedding-resolves-complex-single-cell-trajectories","status":"publish","type":"post","link":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/2017\/09\/22\/reversed-graph-embedding-resolves-complex-single-cell-trajectories\/","title":{"rendered":"Reversed graph embedding resolves complex single-cell trajectories"},"content":{"rendered":"<p>Our next meeting will be at 11:00 on September 26th, in room 4160 of the Discovery building. Our Selected paper is <a href=\"http:\/\/www.nature.com\/nmeth\/journal\/vaop\/ncurrent\/full\/nmeth.4402.html\">Reversed graph embedding resolves complex single-cell trajectories<\/a>.<br \/>\nThe abstract is as follows.<\/p>\n<blockquote><p>Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex trajectories with multiple branches remains a challenging computational problem. We present Monocle 2, an algorithm that uses reversed graph embedding to describe multiple fate decisions in a fully unsupervised manner. We applied Monocle 2 to two studies of blood development and found that mutations in the genes encoding key lineage transcription factors divert cells to alternative fates.<\/p><\/blockquote>\n<p>We welcome all who can join us for this discussion. Feel free to begin that discussion in the comments section below.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our next meeting will be at 11:00 on September 26th, in room 4160 of the Discovery building. Our Selected paper is Reversed graph embedding resolves complex single-cell trajectories. The abstract is as follows. Single-cell trajectories can unveil how gene regulation governs cell fate decisions. However, learning the structure of complex trajectories with multiple branches remains [&hellip;]<\/p>\n","protected":false},"author":197,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[103,133],"tags":[],"_links":{"self":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/566"}],"collection":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/users\/197"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/comments?post=566"}],"version-history":[{"count":1,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/566\/revisions"}],"predecessor-version":[{"id":567,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/posts\/566\/revisions\/567"}],"wp:attachment":[{"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/media?parent=566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/categories?post=566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.discovery.wisc.edu\/sysbiojournalclub\/wp-json\/wp\/v2\/tags?post=566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}