Multiplatform Analysis of 12 Cancer Types Reveals Molecular Classification within and across Tissues of Origin

Katherine A. Hoadley1, 20, Christina Yau2, 20, Denise M. Wolf3, 20, Andrew D. Cherniack4, 20, David Tamborero5, Sam Ng6, Max D.M. Leiserson7, Beifang Niu8, Michael D. McLellan8, Vladislav Uzunangelov6, Jiashan Zhang9, Cyriac Kandoth8, Rehan Akbani10, Hui Shen11, 22, Larsson Omberg12, Andy Chu13, Adam A. Margolin12, 21, Laura J. van’t Veer3, Nuria Lopez-Bigas5, 14, Peter W. Laird11, 22, Benjamin J. Raphael7, Li Ding8, A. Gordon Robertson13, Lauren A. Byers10, Gordon B. Mills10, John N. Weinstein10, Carter Van Waes18, Zhong Chen19, Eric A. Collisson15,The Cancer Genome Atlas Research Network, Christopher C. Benz2, , , Charles M. Perou1, 16, 17, , , Joshua M. Stuart6, ,

1 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
2 Buck Institute for Research on Aging, Novato, CA 94945, USA
3 Department of Laboratory Medicine, University of California San Francisco, 2340 Sutter St, San Francisco, CA, 94115, USA
4 The Eli and Edythe Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
5 Research Unit on Biomedical Informatics, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Dr. Aiguader 88, Barcelona 08003, Spain
6 Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, 1156 High St., Santa Cruz, CA 95064, USA
7 Department of Computer Science and Center for Computational Molecular Biology, Brown University, 115 Waterman St, Providence RI 02912, USA
8 The Genome Institute, Washington University, St Louis, MO 63108, USA
9 National Cancer Institute, NIH, Bethesda, MD 20892, USA
10 UT MD Anderson Cancer Center, Bioinformatics and Computational Biology, 1400 Pressler Street, Unit 1410, Houston, TX 77030, USA
11 USC Epigenome Center, University of Southern California Keck School of Medicine, 1450 Biggy Street, Los Angeles, CA 90033, USA
12 Sage Bionetworks 1100 Fairview Avenue North, M1-C108, Seattle, WA 98109-1024, USA
13 Canada’s Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada
14 Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluís Companys, 23, Barcelona 08010, Spain
15 Department of Medicine, University of California San Francisco, 450 35d St, San Francisco, CA, 94148, USA
16 Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
17 Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 USA
18 Building 10, Room 4-2732, NIDCD/NIH, 10 Center Drive, Bethesda, MD 20892
19 Head and Neck Surgery Branch, NIDCD/NIH, 10 Center Drive, Room 5D55, Bethesda, MD 20892